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Bullous systemic lupus erythematosus (BSLE) is a rare cutaneous . Lúpus eritematoso sistêmico bolhoso – diagnóstico diferencial com dermatite herpetiforme. O lúpus eritematoso sistêmico pode apresentar inúmeras lesões cutâneas. As lesões bolhosas específi cas do lúpus, apesar de raras, apresentam. Systemic lupus erythematosus (SLE) can cause numerous skin lesions. Despite being rare, Lúpus eritematoso sistêmico bolhoso em gestante: relato de caso.

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There was complete remission with dapsone, with no recurrence of skin lesions throughout one year of follow-up. The patient also presented with asthenia, bolhkso fever and a general decline in her health, as well as very large axillary and cervical lymph nodes of 5 months duration.

Am J Clin Dermatol.

Histology from skin biopsy revealed subepidermal blister filled with fibrin, lymphomononuclear cells and lulus, thickening of the basement membrane in the dermal papillae and mild perivascular lymphoplasmacytic infiltrate in the papillary, superficial dermis Figure 4.

Footnotes Conflict of interest: Rio Branco, 39 Discoid lupus erythematosus presenting as acneiform pitting scars.

Autoimmune Diseases

J Pak Med Assoc. It is important to remember that in both EBA and BSLE, anti-type VII collagen antibodies are present in bolhoos sublamina densa of the basement membrane zone and that both conditions have similar genetic characteristics as they are both associated with the HLA-DR2 antigen.

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Direct immunofluorescence reveals a linear or granular deposition of IgG, IgA and C3 in the basement membrane zone.

Find articles by Guilherme Canho Bittner. Int J Dermatol ; Received May 22; Accepted Sep Clinically, BSLE is characterized by a generalized vesiculobullous eruption, non-cicatricial, restricted to photo-exposed areas, or not.

J Am Acad Dermatol. S alt-split was positive for IgG in the dermis and epidermis and for IgA in the epidermis.

Cutaneous Manifestations of Systemic Lupus Erythematosus

Dapsone can induce hypersensitivity syndrome with features similar to those for mononucleosis infection. The patient remained stable during 1 year of follow-up. Adjuvant therapies must also be used in cases that do not respond to or are intolerant of dapsone; the use of azathioprine, antimalarial agents, mycophenolate mofetil and cyclophosphamide has been reported in the literature.

J Low Genit Tract Dis. Other less frequent side effects include neuropathy and bone marrow depression.

Bullous systemic lupus erythematosus in a year-old child

The present case reinforces the bolohso of taking into consideration the various forms of presentation and the atypical behavior of discoid CLE, like the presence of acneiform lesions, bophoso by suggestive signs of CLE, that do not respond to conventional treatment to acne vulgaris.

Bullous systemic lupus erythematosus BSLE is a rare autoimmune subepidermal blistering disease, with few cases described in childhood. Uncommon clinical manifestations, like comedonic lupus can mimic other diseases like acne vulgaris, Favre-Racouchot disease, milium, milia en plaquesyringoma, tricoepithelioma, clustered dilated pores and nevus comedogenic.


The differential diagnosis of comedogenic discoid CLE are: Report of two cases and a review of the literature. Services on Demand Journal. It is caused or triggered by exposure to ultraviolet radiation, cold and drugs and develops gradually. A phenotypically distinctive but immunologically heterogeneous bullous disorder.

There was improvement of the pruritus and the number of comedones Figure 3. The clinical manifestations of CCLE are multiple and varied.

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Bullous systemic lupus erythematosus BSLE is a rare cutaneous manifestation of systemic lupus erythematosus SLEand even more uncommon in the pediatric population 12 It is a heterogenous disease, caused by autoantibodies against the dermo-epidermal junction, particularly type VII collagen.

Blisters are formed as a result of severe damage to the basal layer and consequent separation bohloso the basement membrane from keratinocytes. Open in a separate window.

Journal List An Bras Dermatol v.